Acmella Oleracea extract is considered one of the natural alternative to Botox. It's extracted from a plant called Acmella and when used on the skin it reduces muscle tone thereby reducing facial wrinkles caused by tense or contracted facial muscles. It is therefore seen as a natural muscle relaxant due to the presence of analgesic alkylamides called spilanthol. This spilanthol is thought to have the same paralyzing effects on facial muscles as it does on gums, reducing wrinkles by relaxing the skin. It highly penetrates the skin, inhibiting muscle contractions in subcutaneous muscles underlying the skin. There are several studies which show this products efficacy but one significant study shows that 75% of patients immediately noticed the smoothing effect of Oleracea, and this  are was significant after the first use of the extract. There is one difference between Acmella Oleracea and Botox and that is that it doesn't have collagen-building peptide of Botox.